Dimercaptosuccinic Acid (DMSA), A Non-Toxic, Water-Soluble Treatment For Heavy Metal Toxicity (PDF)
Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound’s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its […]
DMSA and DMPS – Water soluble antidotes for heavy metal poisoning (PDF)
This article reviews the pharmacological properties and the uses of two important antidotes for heavy metal poisoning.
Lead Toxicity Part II: The Role of Free Radical Damage and the Use of Antioxidants in the Pathology and Treatment of Lead Toxicity (PDF)
Antioxidants – vitamins B6, C and E, zinc, taurine, N-acetylcysteine, and alpha-lipoic acid, either alone or in conjunction with standard pharmaceutical chelating agents – have been studied in lead-exposed animals. The evidence for their use in lead exposure, alone and in conjunction with chelating agents, is reviewed in this article.
Mechanisms of detoxification and procedures for detoxification (PDF)
Information on EDTA, DMPS and DMSA.
Metals, Toxicity and Oxidative Stress (PDF)
Metal-induced toxicity and carcinogenicity, with an emphasis on the generation and role of reactive oxygen and nitrogen species, is reviewed.
OXIDATIVE MECHANISMS IN THE TOXICITY OF METAL IONS (PDF)
The role of reactive oxygen species, with the subsequent oxidative deterioration of biological macromolecules in the toxicities associated with transition metal ions, is reviewed.
Relationship between Oxidative Stress and Essential Hypertension (PDF)
These findings demonstrate a strong association between blood pressure and some oxidative stress-related parameters and suggest a possible role of oxidative stress in the pathophysiology of essential hypertension.
The Role of Chronic Inflammation in its Regulation by Nutrients (PDF)
Multiple risk markers for atherosclerosis and cardiovascular disease act in a synergistic way through inflammatory pathways. This article discusses some of the key inflammatory biochemical risk markers for cardiovascular disease; in particular, the role of three basic cell types affected by these risk markers (endothelial cells, smooth muscle cells, and immune cells), the crucial role […]
A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States (PDF)
It is clear from the results of the present epidemiological study and other recently published data associating mercury exposure with childhood NDs, additional ND research should be undertaken in the context of evaluating mercury-associated exposures, especially from Thimerosal-containing vaccines.