This pilot study indicates the promise of nebulized buffered GSH to ameliorate CF disease, and longer, larger, and improved studies of inhaled GSH are warranted.
Author Archive | Jason Lovoy
Cystic Fibrosis: Therapeutic Options For Co-management (PDF)
CF is a disease of greatly varied symptomatology due to the many possible mutations contributing to genotype and phenotype. This creates a disease complex with a wide range of disorders that can ultimately include chronic obstructive pulmonary disease, CF-associated liver fibrosis, diabetes mellitus, cholelithiasis, and arthritis.
Improved antioxidant and fatty acid status of patients with cystic fibrosis after antioxidant supplementation is linked to improved lung function (PDF)
Whereas increased -carotene, selenium, and fatty acid concentrations are linked to improved lung function, increased plasma fatty acid concentrations are linked to oxidative stress. If oxidative stress is deemed to be important to the clinical outcome of CF patients, means of reducing oxidative stress while maintaining a high-fat, high-energy diet must be investigated.
Lymphocyte Glutathione Levels in Children With Cystic Fibrosis (PDF)
We interpret the inverse correlation between lymphocyte GSH concentration and lung function as a reflection of upregulation of GSH production by lung epithelial tissue in response to oxidative stress. We interpret the correlation between lymphocyte GSH concentration and nutritional status as a reflection of the role of cysteine in hepatic glutamine metabolism. Peripheral blood lymphocyte […]
Chronic fatigue syndrome: assessment of increased oxidative stress and altered muscle excitability in response to incremental exercise (PDF)
The response of CFS patients to incremental exercise associates a lengthened and accentuated oxidative stress together with marked alterations of the muscle membrane excitability. These two objective signs of muscle dysfunction are sufficient to explain muscle pain and postexertional malaise reported by our patients.
Chronic Fatigue Syndrome: Oxidative Stress and Dietary Modifications
Chronic fatigue syndrome (CFS) is an illness characterized by persistent and relapsing fatigue, often accompanied by numerous symptoms involving various body systems. The etiology of CFS remains unclear; however, a number of recent studies have shown oxidative stress may be involved in its pathogenesis. The role of oxidative stress in CFS is an important area […]
The chronic fatigue syndrome – an update (PDF)
Cognitive behavioural therapy and graded exercise therapy are of proven value in randomized controlled trials. Several pharmaceutical measures have been explored and found to have no beneficial effect. Most patients might expect long-term improvement, but full recovery is rare; however, the prognosis is better among adolescents.
Chelation Therapy: An alternative approach to vascular disease (PDF)
Dimercaptosuccinic Acid (DMSA), A Non-Toxic, Water-Soluble Treatment For Heavy Metal Toxicity (PDF)
Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound’s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its […]
DMSA and DMPS – Water soluble antidotes for heavy metal poisoning (PDF)
This article reviews the pharmacological properties and the uses of two important antidotes for heavy metal poisoning.