These data confirm the established role of oxidant/antioxidant imbalance in the pathogenesis of idiopathic pulmonary fibrosis, and show the potential of induced sputum to directly study inflammatory processes and surrogate markers in interstitial lung diseases like idiopathic pulmonary fibrosis.
Author Archive | Jason Lovoy
Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease (PDF)
By Jason Lovoy on 2015-05-26 in Glutathione in Chronic Obstructive Pulmonary Disease, Resource Library
This review outlines 1) the regulation of cellular GSH levels and g-GCS expression under oxidative stress and 2) the evidence for lung oxidant stress and the potential role of GSH in the pathogenesis of COPD.
Oxidative stress and regulation of glutathione in lung inflammation (PDF)
By Jason Lovoy on 2015-05-26 in Glutathione in Chronic Obstructive Pulmonary Disease, Resource Library
This review describes the redox control and involvement of nuclear factor-kB and activator protein-1 in the regulation of cellular glutathione and c-glutamylcysteine synthetase under conditions of oxidative stress and inflammation, the role of glutathione in oxidant-mediated susceptibility/tolerance, c-glutamylcysteine synthetase genetic susceptibility and the potential therapeutic role of glutathione and its precursors in protecting against lung […]
The Treatment of Pulmonary Diseases and Respiratory-Related Conditions with Inhaled (Nebulized or Aerosolized) Glutathione (PDF)
By Jason Lovoy on 2015-05-26 in Glutathione in Chronic Obstructive Pulmonary Disease, Resource Library
The potential applications of inhaled GSH are numerous when one considers just how many pulmonary diseases and respiratory-related conditions are affected by deficient antioxidant status or an over production of oxidants, poor oxygenation and/or impaired host defenses.
The Use of Nebulized Glutathione in the Treatment of Emphysema: a Case Report (PDF)
By Jason Lovoy on 2015-05-26 in Glutathione in Chronic Obstructive Pulmonary Disease, Resource Library
We present the case of a 95-year-old man with an acute respiratory crisis secondary to emphysema and apparent bronchial infection. Treatment with nebulized glutathione led to a rapid resolution of the crisis, as well as a marked improvement in the chronic course of the disease. This treatment has been used since for a number of […]
A critical role of glutathione in determining apoptosis sensitivity and resistance in leukemia cells (PDF)
We conclude that dominant apoptosis resistance depends, at least in part, on intracellular GSH levels, which may affect apoptosis signaling at different compartments, for example, the death receptor or mitochondria.
Glutathione reduces the toxicity and improves quality of life of women diagnosed with ovarian cancer treated with cisplatin: Results of a doubleblind, randomised trial (PDF)
Early clinical trials have suggested that glutathione (GSH) offers protection from the toxic effects of cisplatin.
Glutathione Monograph (PDF)
TREATMENT OF CONSECUTIVE SEVERE FIBROMYALGIA PATIENTS WITH PROLOTHERAPY (PDF)
The potential of tendon and ligament triggers as primary nociceptors in fibromyalgia led to treatment of primary fibromyalgia patients with tendon and ligament strengthening injection. Trigger injection of ligament and tendon with proliferant (TILT therapy or prolotherapy) offers the advantage of creating increased strength of the connective tissue in the region of injection as well […]
A new model of cystic fibrosis pathology: Lack of transport of glutathione and its thiocyanate conjugates (PDF)
Many of the symptoms of cystic fibrosis are not explained by the current disease mechanisms. Therefore, the authors conducted an extensive literature review and present a new model of cystic fibrosis pathology, which is the culmination of this research. Understanding that the cystic fibrosis transmembrane conductance regulator (CFTR) is responsible for glutathione (GSH) transport, the […]